The Ubiquitin-Proteasome Pathway in Huntington's Disease

The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity. Accompanying neuronal death, mutant huntingtin aggregates in large macromolecular structures called inclu...

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Detalles Bibliográficos
Autores principales: Mitra, Siddhartha, Finkbeiner, Steven
Formato: Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637619/
https://www.ncbi.nlm.nih.gov/pubmed/18454252
http://dx.doi.org/10.1100/tsw.2008.60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637619/
https://www.ncbi.nlm.nih.gov/pubmed/18454252
http://dx.doi.org/10.1100/tsw.2008.60

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