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Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats

This paper connects Alu repeats, the most abundant repetitive elements in the human genome and microRNAs, small RNAs that alter gene expression at the post-transcriptional level. Base-pair complementarity could be demonstrated between the seed sequence of a subset of human microRNAs and Alu repeats...

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Detalles Bibliográficos
Autores principales: Lehnert, Stefan, Van Loo, Peter, Thilakarathne, Pushpike J., Marynen, Peter, Verbeke, Geert, Schuit, Frans C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637760/
https://www.ncbi.nlm.nih.gov/pubmed/19209240
http://dx.doi.org/10.1371/journal.pone.0004456
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author Lehnert, Stefan
Van Loo, Peter
Thilakarathne, Pushpike J.
Marynen, Peter
Verbeke, Geert
Schuit, Frans C.
author_facet Lehnert, Stefan
Van Loo, Peter
Thilakarathne, Pushpike J.
Marynen, Peter
Verbeke, Geert
Schuit, Frans C.
author_sort Lehnert, Stefan
collection PubMed
description This paper connects Alu repeats, the most abundant repetitive elements in the human genome and microRNAs, small RNAs that alter gene expression at the post-transcriptional level. Base-pair complementarity could be demonstrated between the seed sequence of a subset of human microRNAs and Alu repeats that are integrated parallel (sense) in mRNAs. The most common target site coincides with the evolutionary most conserved part of Alu. A primate-specific gene cluster on chromosome 19 encodes the majority of miRNAs that target the most conserved sense Alu site. The individual miRNA genes within this cluster are flanked by an Alu-LINE signature, which has been duplicated with the clustered miRNA genes. Gene duplication events in this locus are supported by comparing repeat length variations of the LINE elements within the cluster with those in the rest of the chromosome. Thus, a dual relationship exists between an evolutionary young miRNA cluster and their Alu targets that may have evolved in the same time window. One hypothesis for this dual relationship is that these miRNAs could protect against too high rates of duplicative transposition, which would destroy the genome.
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spelling pubmed-26377602009-02-11 Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats Lehnert, Stefan Van Loo, Peter Thilakarathne, Pushpike J. Marynen, Peter Verbeke, Geert Schuit, Frans C. PLoS One Research Article This paper connects Alu repeats, the most abundant repetitive elements in the human genome and microRNAs, small RNAs that alter gene expression at the post-transcriptional level. Base-pair complementarity could be demonstrated between the seed sequence of a subset of human microRNAs and Alu repeats that are integrated parallel (sense) in mRNAs. The most common target site coincides with the evolutionary most conserved part of Alu. A primate-specific gene cluster on chromosome 19 encodes the majority of miRNAs that target the most conserved sense Alu site. The individual miRNA genes within this cluster are flanked by an Alu-LINE signature, which has been duplicated with the clustered miRNA genes. Gene duplication events in this locus are supported by comparing repeat length variations of the LINE elements within the cluster with those in the rest of the chromosome. Thus, a dual relationship exists between an evolutionary young miRNA cluster and their Alu targets that may have evolved in the same time window. One hypothesis for this dual relationship is that these miRNAs could protect against too high rates of duplicative transposition, which would destroy the genome. Public Library of Science 2009-02-11 /pmc/articles/PMC2637760/ /pubmed/19209240 http://dx.doi.org/10.1371/journal.pone.0004456 Text en Lehnert et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lehnert, Stefan
Van Loo, Peter
Thilakarathne, Pushpike J.
Marynen, Peter
Verbeke, Geert
Schuit, Frans C.
Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title_full Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title_fullStr Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title_full_unstemmed Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title_short Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
title_sort evidence for co-evolution between human micrornas and alu-repeats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637760/
https://www.ncbi.nlm.nih.gov/pubmed/19209240
http://dx.doi.org/10.1371/journal.pone.0004456
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