Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor rapamycin and ac...

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Detalles Bibliográficos
Autores principales: Feldman, Morris E, Apsel, Beth, Uotila, Aino, Loewith, Robbie, Knight, Zachary A, Ruggero, Davide, Shokat, Kevan M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637922/
https://www.ncbi.nlm.nih.gov/pubmed/19209957
http://dx.doi.org/10.1371/journal.pbio.1000038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637922/
https://www.ncbi.nlm.nih.gov/pubmed/19209957
http://dx.doi.org/10.1371/journal.pbio.1000038

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