Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair

Polymerase mu (Polμ) is an error-prone, DNA-directed DNA polymerase that participates in non-homologous end-joining (NHEJ) repair. In vivo, Polμ deficiency results in impaired Vκ-Jκ recombination and altered somatic hypermutation and centroblast development. In Polμ(−/−) mice, hematopoietic developm...

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Detalles Bibliográficos
Autores principales: Lucas, Daniel, Escudero, Beatriz, Ligos, José Manuel, Segovia, Jose Carlos, Estrada, Juan Camilo, Terrados, Gloria, Blanco, Luis, Samper, Enrique, Bernad, Antonio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638008/
https://www.ncbi.nlm.nih.gov/pubmed/19229323
http://dx.doi.org/10.1371/journal.pgen.1000389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638008/
https://www.ncbi.nlm.nih.gov/pubmed/19229323
http://dx.doi.org/10.1371/journal.pgen.1000389

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