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Four Ca(2+) Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate

TRPM2 is a tetrameric Ca(2+)-permeable channel involved in immunocyte respiratory burst and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular ADP ribose (ADPR) and intra- or extracellular Ca(2+), but the mechanism and the binding sites for Ca(2+) activation remai...

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Detalles Bibliográficos
Autores principales: Csanády, László, Törőcsik, Beáta
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638199/
https://www.ncbi.nlm.nih.gov/pubmed/19171771
http://dx.doi.org/10.1085/jgp.200810109