Cargando…
Four Ca(2+) Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
TRPM2 is a tetrameric Ca(2+)-permeable channel involved in immunocyte respiratory burst and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular ADP ribose (ADPR) and intra- or extracellular Ca(2+), but the mechanism and the binding sites for Ca(2+) activation remai...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638199/ https://www.ncbi.nlm.nih.gov/pubmed/19171771 http://dx.doi.org/10.1085/jgp.200810109 |