Pentobarbital Produces Activation and Block of α(1)β(2)γ(2S) GABA(A) Receptors in Rapidly Perfused Whole Cells and Membrane Patches: Divergent Results Can Be Explained by Pharmacokinetics

Millimolar concentrations of the barbiturate pentobarbital (PB) activate γ-aminobutyric acid (GABA) type A receptors (GABARs) and cause blockade reported by a paradoxical current increase or “tail” upon washout. To explore the mechanism of blockade, we investigated PB-triggered currents of recombina...

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Detalles Bibliográficos
Autores principales: Gingrich, Kevin J., Burkat, Paul M., Roberts, William A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638204/
https://www.ncbi.nlm.nih.gov/pubmed/19171770
http://dx.doi.org/10.1085/jgp.200810081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638204/
https://www.ncbi.nlm.nih.gov/pubmed/19171770
http://dx.doi.org/10.1085/jgp.200810081

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