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Decremental Response to High-Frequency Trains of Acetylcholine Pulses but Unaltered Fractional Ca(2+) Currents in a Panel of “Slow-Channel Syndrome” Nicotinic Receptor Mutants
The slow-channel congenital myasthenic syndrome (SCCMS) is a disorder of the neuromuscular junction caused by gain-of-function mutations to the muscle nicotinic acetylcholine (ACh) receptor (AChR). Although it is clear that the slower deactivation time course of the ACh-elicited currents plays a cen...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638206/ https://www.ncbi.nlm.nih.gov/pubmed/19171769 http://dx.doi.org/10.1085/jgp.200810089 |