Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa

OBJECTIVES: Resistance to pyrimethamine in Plasmodium falciparum is conferred by mutations in the gene encoding dihydrofolate reductase (DHFR). It is known that DHFR double mutants have evolved independently in multiple geographic areas, whereas the triple mutant prevalent in Africa appears to have...

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Detalles Bibliográficos
Autores principales: Mita, Toshihiro, Tanabe, Kazuyuki, Takahashi, Nobuyuki, Culleton, Richard, Ndounga, Mathieu, Dzodzomenyo, Mawuli, Akhwale, Willis S., Kaneko, Akira, Kobayakawa, Takatoshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639266/
https://www.ncbi.nlm.nih.gov/pubmed/19036751
http://dx.doi.org/10.1093/jac/dkn482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639266/
https://www.ncbi.nlm.nih.gov/pubmed/19036751
http://dx.doi.org/10.1093/jac/dkn482

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