Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

BACKGROUND: Cisplatin is a cornerstone anticancer drug with pronounced ototoxicity, whereas oxaliplatin, a platinum derivative with a different clinical profile, is rarely ototoxic. This difference has not been explained. METHODS: In HCT116 cells, cisplatin (20 μM)-induced apoptosis was reduced by a...

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Detalles Bibliográficos
Autores principales: Hellberg, Victoria, Wallin, Inger, Eriksson, Sofi, Hernlund, Emma, Jerremalm, Elin, Berndtsson, Maria, Eksborg, Staffan, Arnér, Elias S. J., Shoshan, Maria, Ehrsson, Hans, Laurell, Göran
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639295/
https://www.ncbi.nlm.nih.gov/pubmed/19116379
http://dx.doi.org/10.1093/jnci/djn418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639295/
https://www.ncbi.nlm.nih.gov/pubmed/19116379
http://dx.doi.org/10.1093/jnci/djn418

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