The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation

Human leukocyte receptor IIIa (FcγRIIIa) plays an important role in mediating therapeutic antibodies’ antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo. The removal of the core fucose from oligosaccharides att...

Descripción completa

Detalles Bibliográficos
Autores principales: Shibata-Koyama, Mami, Iida, Shigeru, Okazaki, Akira, Mori, Katsuhiro, Kitajima-Miyama, Kazuko, Saitou, Seiji, Kakita, Shingo, Kanda, Yutaka, Shitara, Kenya, Kato, Koichi, Satoh, Mitsuo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639328/
https://www.ncbi.nlm.nih.gov/pubmed/18952826
http://dx.doi.org/10.1093/glycob/cwn110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639328/
https://www.ncbi.nlm.nih.gov/pubmed/18952826
http://dx.doi.org/10.1093/glycob/cwn110

Ejemplares similares