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The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation

Human leukocyte receptor IIIa (FcγRIIIa) plays an important role in mediating therapeutic antibodies’ antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo. The removal of the core fucose from oligosaccharides att...

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Detalles Bibliográficos
Autores principales:	Shibata-Koyama, Mami, Iida, Shigeru, Okazaki, Akira, Mori, Katsuhiro, Kitajima-Miyama, Kazuko, Saitou, Seiji, Kakita, Shingo, Kanda, Yutaka, Shitara, Kenya, Kato, Koichi, Satoh, Mitsuo
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639328/ https://www.ncbi.nlm.nih.gov/pubmed/18952826 http://dx.doi.org/10.1093/glycob/cwn110

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