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Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease
Background. Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts in animal models of human ARPKD (PCK rat) and/or ADPKD (Pkd2(−/WS25) mouse). A calcium-sensing receptor (CaR) is expressed in various tubula...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639335/ https://www.ncbi.nlm.nih.gov/pubmed/18826972 http://dx.doi.org/10.1093/ndt/gfn527 |