Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3

Mutations in the superoxide dismutase 1 (sod1) gene cause familial amyotrophic lateral sclerosis (FALS), likely due to the toxic properties of misfolded mutant SOD1 protein. Here we demonstrated that, starting from the pre-onset stage of FALS, misfolded SOD1 species associates specifically with kine...

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Detalles Bibliográficos
Autores principales: Tateno, Minako, Kato, Shinsuke, Sakurai, Takashi, Nukina, Nobuyuki, Takahashi, Ryosuke, Araki, Toshiyuki
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640210/
https://www.ncbi.nlm.nih.gov/pubmed/19088126
http://dx.doi.org/10.1093/hmg/ddn422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640210/
https://www.ncbi.nlm.nih.gov/pubmed/19088126
http://dx.doi.org/10.1093/hmg/ddn422

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