Targeted Inactivation of p12(Cdk2ap1), CDK2 Associating Protein 1, Leads to Early Embryonic Lethality

Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate. Detailed timed pregnancy analysis of embryos showed that the lethality occurred between embryonic day 3.5 pc and 5.5 pc, a period of implan...

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Detalles Bibliográficos
Autores principales: Kim, Yong, McBride, Jim, Kimlin, Lauren, Pae, Eung-Kwon, Deshpande, Amit, Wong, David T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641017/
https://www.ncbi.nlm.nih.gov/pubmed/19229340
http://dx.doi.org/10.1371/journal.pone.0004518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641017/
https://www.ncbi.nlm.nih.gov/pubmed/19229340
http://dx.doi.org/10.1371/journal.pone.0004518

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