Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

BACKGROUND: We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inflammation and mortality at postnatal day 1 due to TNF-induced epithelial cell death. Although deletion of TNF receptor 1 (TNFR1) can largely rescue those neonatal phenotypes, mice harborin...

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Detalles Bibliográficos
Autores principales: Kim, Jae-Young, Kajino-Sakamoto, Rie, Omori, Emily, Jobin, Christian, Ninomiya-Tsuji, Jun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642721/
https://www.ncbi.nlm.nih.gov/pubmed/19234607
http://dx.doi.org/10.1371/journal.pone.0004561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642721/
https://www.ncbi.nlm.nih.gov/pubmed/19234607
http://dx.doi.org/10.1371/journal.pone.0004561

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