Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

Genetic background exerts a strong modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifier genes may affect the molecular processes leadin...

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Detalles Bibliográficos
Autores principales: Gidalevitz, Tali, Krupinski, Thomas, Garcia, Susana, Morimoto, Richard I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642731/
https://www.ncbi.nlm.nih.gov/pubmed/19266020
http://dx.doi.org/10.1371/journal.pgen.1000399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642731/
https://www.ncbi.nlm.nih.gov/pubmed/19266020
http://dx.doi.org/10.1371/journal.pgen.1000399

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