Cargando…

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

Genetic background exerts a strong modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifier genes may affect the molecular processes leadin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gidalevitz, Tali, Krupinski, Thomas, Garcia, Susana, Morimoto, Richard I.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642731/ https://www.ncbi.nlm.nih.gov/pubmed/19266020 http://dx.doi.org/10.1371/journal.pgen.1000399

Ejemplares similares

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity
por: McAlary, Luke, et al.
Publicado: (2016)

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease
por: Gidalevitz, Tali, et al.
Publicado: (2013)

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1
por: Prudencio, Mercedes, et al.
Publicado: (2010)

Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation in Drosophila melanogaster
por: Lessel, Courtney E., et al.
Publicado: (2017)

Ubiquitylation Directly Induces Fold Destabilization of Proteins
por: Morimoto, Daichi, et al.
Publicado: (2016)

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
por: Joyce, Peter I., et al.
Publicado: (2015)

A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein
por: Klabonski, Lauren, et al.
Publicado: (2016)

Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans
por: Boccitto, Marco, et al.
Publicado: (2012)

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
por: Vehviläinen, Piia, et al.
Publicado: (2014)

Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1
por: Brasil, Aline de Araújo, et al.
Publicado: (2019)

Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background
por: Kawakami-Schulz, Sharolyn V., et al.
Publicado: (2012)

Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice
por: Tolman, Nicholas G., et al.
Publicado: (2021)

Nuclear genetic background influences the phenotype of the Drosophila tko(25t) mitochondrial protein-synthesis mutant
por: Jacobs, Howard T, et al.
Publicado: (2023)

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS
por: Shteinfer-Kuzmine, Anna, et al.
Publicado: (2019)

Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis
por: Kim, Sang-Hoon, et al.
Publicado: (2015)

The RIDD activity of C. elegans IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survival
por: Mingjie, Ying, et al.
Publicado: (2023)

Oxidation destabilizes toxic amyloid beta peptide aggregation
por: Razzokov, J., et al.
Publicado: (2019)

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
por: Qiu, Linghua, et al.
Publicado: (2013)

SOD2 polymorphisms: unmasking the effect of polymorphism on splicing
por: Shao, Jing, et al.
Publicado: (2007)

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons
por: Kumar, Meenakshi Sundaram, et al.
Publicado: (2022)

The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice
por: Shi, Yun, et al.
Publicado: (2014)

Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS
por: Nordström, Ulrika, et al.
Publicado: (2022)

Association between Genetic Polymorphisms of SOD2 G1677T and 50 bp I/D of SOD1 with the Risk of Colorectal Cancer
por: Vosough, Parisa, et al.
Publicado: (2021)

Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity
por: Wang, Yiru A., et al.
Publicado: (2019)

Computational Insights into the Unfolding of a Destabilized Superoxide Dismutase 1 Mutant
por: Timr, Stepan, et al.
Publicado: (2021)

Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus
por: Powell, Anahid E., et al.
Publicado: (2011)

Effects of Cu/Zn Superoxide Dismutase (sod1) Genotype and Genetic Background on Growth, Reproduction and Defense in Biomphalaria glabrata
por: Bonner, Kaitlin M., et al.
Publicado: (2012)

The structure–function relationships and physiological roles of MnSOD mutants
por: Bonetta Valentino, Rosalin
Publicado: (2022)

Association of temperament with genetic polymorphisms in SOD1, GSTM1 and GSTT1 genes
por: Zendehboodi, Zahra, et al.
Publicado: (2021)

Better survival in female SOD1-mutant patients with ALS: a study of SOD1-related natural history
por: Tang, Lu, et al.
Publicado: (2019)

Genetic induction of hypometabolism by ablation of MC4R does not suppress ALS-like phenotypes in the G93A mutant SOD1 mouse model
por: Doshi, Shachee, et al.
Publicado: (2017)

Rhodopsin Mutant P23H Destabilizes Rod Photoreceptor Disk Membranes
por: Haeri, Mohammad, et al.
Publicado: (2012)

Prediction of Protein-Destabilizing Polymorphisms by Manual Curation with Protein Structure
por: Gough, Craig Alan, et al.
Publicado: (2012)

Alterations in Concentration/Activity of Superoxide Dismutases in Context of Obesity and Selected Single Nucleotide Polymorphisms in Genes: SOD1, SOD2, SOD3
por: Lewandowski, Łukasz, et al.
Publicado: (2020)

Polymorphisms in the Mn-SOD and EC-SOD Genes and Their Relationship to Diabetic Neuropathy in Type 1 Diabetes Mellitus
por: Chistyakov, Dimitry A, et al.
Publicado: (2001)

EHMTI-0241. Association between migraine and sod1 and sod2 genes polymorphisms: the biobim study
por: Barbanti, P, et al.
Publicado: (2014)

Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
por: MARGINEAN, C., et al.
Publicado: (2016)

Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients
por: Emene, Charles C., et al.
Publicado: (2017)

RNAi phenotypes are influenced by the genetic background of the injected strain
por: Kitzmann, Peter, et al.
Publicado: (2013)

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response
por: Zha, Ji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bv3bd233h5bppbqeh8mlh5o2oq