Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radio-resistance

Recent reports implicate poly(ADP-ribose) polymerase-1 (PARP-1) in the activation of NF-κB. We investigated the role of PARP-1 in the NF-κB signalling cascade induced by ionizing radiation (IR). AG14361, a potent PARP-1 inhibitor, was used in two breast cancer cell lines expressing different levels...

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Detalles Bibliográficos
Autores principales: Veuger, Stephany J., Hunter, Jill E., Durkacz, Barbara W.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642763/
https://www.ncbi.nlm.nih.gov/pubmed/19060926
http://dx.doi.org/10.1038/onc.2008.439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642763/
https://www.ncbi.nlm.nih.gov/pubmed/19060926
http://dx.doi.org/10.1038/onc.2008.439

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