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Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radio-resistance
Recent reports implicate poly(ADP-ribose) polymerase-1 (PARP-1) in the activation of NF-κB. We investigated the role of PARP-1 in the NF-κB signalling cascade induced by ionizing radiation (IR). AG14361, a potent PARP-1 inhibitor, was used in two breast cancer cell lines expressing different levels...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642763/ https://www.ncbi.nlm.nih.gov/pubmed/19060926 http://dx.doi.org/10.1038/onc.2008.439 |