Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

BACKGROUND: C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared with C57BL6/J (B6) mice, as observed by the presence of the leptin receptor (Lepr) allele, Lepr(db/db). Furthermore, DBA2/J (DBA) mice are also susceptible to β-cell failure and share 25% of...

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Detalles Bibliográficos
Autores principales: Anderson, Abraham A, Helmering, Joan, Juan, Todd, Li, Chi-Ming, McCormick, Jocelyn, Graham, Melissa, Baker, Daniel M, Damore, Michael A, Véniant, Murielle M, Lloyd, David J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642818/
https://www.ncbi.nlm.nih.gov/pubmed/19161594
http://dx.doi.org/10.1186/1755-8417-2-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642818/
https://www.ncbi.nlm.nih.gov/pubmed/19161594
http://dx.doi.org/10.1186/1755-8417-2-1

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