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HDX-ESI-MS Reveals Enhanced Conformational Dynamics of the Amyloidogenic Protein β(2)-Microglobulin upon Release from the MHC-1
The light chain of the major histocompatibility complex class 1 (MHC-1), the protein β(2)-microglobulin (β(2)m), has amyloidogenic properties that arise only upon its dissociation from the MHC-1. Here hydrogen/deuterium exchange electrospray ionization mass spectrometry (HDX-ESI-MS) has been used to...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
ACS Publications
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642988/ https://www.ncbi.nlm.nih.gov/pubmed/18996721 http://dx.doi.org/10.1016/j.jasms.2008.10.005 |