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Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
Target recognition in RNA silencing is governed by the “seed sequence” of a guide RNA strand associated with the PIWI/MID domain of an Argonaute protein in RISC. Using a reconstituted in vitro target recognition system, we show that a model PIWI/MID domain protein confers position-dependent tighteni...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642989/ https://www.ncbi.nlm.nih.gov/pubmed/19187762 http://dx.doi.org/10.1016/j.molcel.2008.12.012 |