A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

Protein cleavage is a central event in many regulated biological processes. We describe a system for detecting intracellular proteolysis based on non-conventional secretion of Gaussia luciferase (GLUC). GLUC exits the cell without benefit of a secretory leader peptide, but can be anchored in the cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Ketteler, Robin, Sun, Zairen, Kovacs, Karl F, He, Wei-Wu, Seed, Brian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643935/
https://www.ncbi.nlm.nih.gov/pubmed/18387192
http://dx.doi.org/10.1186/gb-2008-9-4-r64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643935/
https://www.ncbi.nlm.nih.gov/pubmed/18387192
http://dx.doi.org/10.1186/gb-2008-9-4-r64

Ejemplares similares