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A pathway sensor for genome-wide screens of intracellular proteolytic cleavage
Protein cleavage is a central event in many regulated biological processes. We describe a system for detecting intracellular proteolysis based on non-conventional secretion of Gaussia luciferase (GLUC). GLUC exits the cell without benefit of a secretory leader peptide, but can be anchored in the cel...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643935/ https://www.ncbi.nlm.nih.gov/pubmed/18387192 http://dx.doi.org/10.1186/gb-2008-9-4-r64 |