Linear combinations of docking affinities explain quantitative differences in RTK signaling

Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. Binary, ‘on–off' wiring diagrams are therefore inadequate to explain their dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Gordus, Andrew, Krall, Jordan A, Beyer, Elsa M, Kaushansky, Alexis, Wolf-Yadlin, Alejandro, Sevecka, Mark, Chang, Bryan H, Rush, John, MacBeath, Gavin
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644171/
https://www.ncbi.nlm.nih.gov/pubmed/19156127
http://dx.doi.org/10.1038/msb.2008.72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644171/
https://www.ncbi.nlm.nih.gov/pubmed/19156127
http://dx.doi.org/10.1038/msb.2008.72

Ejemplares similares