Novel mutations in the VKORC1 gene of wild rats and mice – a response to 50 years of selection pressure by warfarin?

BACKGROUND: Coumarin derivatives have been in world-wide use for rodent pest control for more than 50 years. Due to their retarded action as inhibitors of blood coagulation by repression of the vitamin K reductase (VKOR) activity, they are the rodenticides of choice against several species. Resistan...

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Detalles Bibliográficos
Autores principales: Rost, Simone, Pelz, Hans-Joachim, Menzel, Sandra, MacNicoll, Alan D, León, Vanina, Song, Ki-Joon, Jäkel, Thomas, Oldenburg, Johannes, Müller, Clemens R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644709/
https://www.ncbi.nlm.nih.gov/pubmed/19200363
http://dx.doi.org/10.1186/1471-2156-10-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644709/
https://www.ncbi.nlm.nih.gov/pubmed/19200363
http://dx.doi.org/10.1186/1471-2156-10-4

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