Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylation

BACKGROUND: Two hairpin structures that are present at both the 5' and 3' end of the HIV-1 RNA genome have important functions in the viral life cycle. The TAR hairpin binds the viral Tat protein and is essential for Tat-mediated activation of transcription. The adjacent polyA hairpin enco...

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Detalles Bibliográficos
Autores principales: Vrolijk, Martine M, Harwig, Alex, Berkhout, Ben, Das, Atze T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645353/
https://www.ncbi.nlm.nih.gov/pubmed/19210761
http://dx.doi.org/10.1186/1742-4690-6-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645353/
https://www.ncbi.nlm.nih.gov/pubmed/19210761
http://dx.doi.org/10.1186/1742-4690-6-13

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