Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

In this study, the potential role of Stat3 in UVB-induced skin carcinogenesis was examined using skin-specific gain and loss of function transgenic mice, i.e., K5.Stat3C and K5Cre.Stat3(fl/fl) mice, respectively. The epidermis of Stat3-deficient mice was highly sensitive to UVB-induced apoptosis, wh...

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Detalles Bibliográficos
Autores principales: Kim, Dae Joon, Angel, Joe M., Sano, Shigetoshi, DiGiovanni, John
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645481/
https://www.ncbi.nlm.nih.gov/pubmed/19137019
http://dx.doi.org/10.1038/onc.2008.453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645481/
https://www.ncbi.nlm.nih.gov/pubmed/19137019
http://dx.doi.org/10.1038/onc.2008.453

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