Cargando…

Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

In this study, the potential role of Stat3 in UVB-induced skin carcinogenesis was examined using skin-specific gain and loss of function transgenic mice, i.e., K5.Stat3C and K5Cre.Stat3(fl/fl) mice, respectively. The epidermis of Stat3-deficient mice was highly sensitive to UVB-induced apoptosis, wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Dae Joon, Angel, Joe M., Sano, Shigetoshi, DiGiovanni, John
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645481/ https://www.ncbi.nlm.nih.gov/pubmed/19137019 http://dx.doi.org/10.1038/onc.2008.453

Ejemplares similares

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation
por: Kim, Dae Joon, et al.
Publicado: (2010)

Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation
por: Aparicio-Siegmund, Samadhi, et al.
Publicado: (2014)

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection
por: Shukla, Shirish, et al.
Publicado: (2010)

Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
por: Macias, Everardo, et al.
Publicado: (2013)

UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation
por: Kim, Mihwa, et al.
Publicado: (2017)

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes
por: Karras, James G., et al.
Publicado: (1997)

Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways
por: Sha, Yan, et al.
Publicado: (2018)

Ras and Raf pathways in epidermis development and carcinogenesis
por: Kern, F, et al.
Publicado: (2011)

Ras and Raf pathways in epidermis development and carcinogenesis
por: Kern, F, et al.
Publicado: (2011)

Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development
por: Lee, Hyunseung, et al.
Publicado: (2017)

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis
por: Conney, Allan H., et al.
Publicado: (2013)

Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
por: Patel, Amit K, et al.
Publicado: (2013)

Signal transducer and activator of transcription 3 (STAT3) promoter methylation and expression in pituitary adenoma
por: Valiulyte, Indre, et al.
Publicado: (2017)

Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor
por: McCann, Georgia A., et al.
Publicado: (2014)

MC5R Contributes to Sensitivity to UVB Waves and Barrier Function in Mouse Epidermis
por: Shintani, Akari, et al.
Publicado: (2021)

Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC)
por: Codony-Servat, Carles, et al.
Publicado: (2017)

The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
por: Wynder, E. L., et al.
Publicado: (1970)

Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
por: Madani, Aisha Y., et al.
Publicado: (2021)

Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
por: Yun, Sun, et al.
Publicado: (2021)

Protein expression under sustained activation of signal transducer and activator of transcription-3 in diethylnitrosamine-induced rat liver carcinogenesis
por: CUI, LI-MIN, et al.
Publicado: (2014)

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
por: Arora, Loukik, et al.
Publicado: (2018)

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors
por: Furtek, Steffanie L., et al.
Publicado: (2016)

Langerhans Cells Facilitate UVB-induced Epidermal Carcinogenesis
por: Lewis, Julia M., et al.
Publicado: (2015)

Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
por: Hsiao, J-R, et al.
Publicado: (2003)

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3
por: Yeo, In Jun, et al.
Publicado: (2018)

Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation
por: Zhang, Mao Xiu, et al.
Publicado: (2010)

Therapeutic Targeting of STAT3 (Signal Transducers and Activators of Transcription 3) Pathway Inhibits Experimental Autoimmune Uveitis
por: Yu, Cheng-Rong, et al.
Publicado: (2012)

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic‐ischaemic brain damage
por: Hristova, Mariya, et al.
Publicado: (2016)

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
por: Gargantilla, Marta, et al.
Publicado: (2022)

The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB
por: Hämäläinen, L., et al.
Publicado: (2021)

Inhibition of STAT3 Reduces Astrocytoma Cell Invasion and Constitutive Activation of STAT3 Predicts Poor Prognosis in Human Astrocytoma
por: Liang, Qinchuan, et al.
Publicado: (2013)

Essential Role of Signal Transducer and Activator of Transcription (Stat)5a but Not Stat5b for Flt3-Dependent Signaling
por: Zhang, Shuli, et al.
Publicado: (2000)

14-3-3ζ Interacts with Stat3 and Regulates Its Constitutive Activation in Multiple Myeloma Cells
por: Zhang, Jia, et al.
Publicado: (2012)

STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1
por: Picco, María Elisa, et al.
Publicado: (2019)

Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer
por: Yousuf, Saad, et al.
Publicado: (2014)

Patient Characteristics Influence Activated Signal Transducer and Activator of Transcription 3 (STAT3) Levels in Primary Breast Cancer—Impact on Prognosis
por: Nilsson, Linn, et al.
Publicado: (2020)

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
por: Ray, Sutapa, et al.
Publicado: (2008)

Signal transducer and activator of transcription 3 (STAT3) controls susceptibility to Epstein-Barr virus reactivation in B cells
por: Hill, Erik R, et al.
Publicado: (2012)

Qizhufang (ZSF) Ameliorates Hepatic Iron Overload via Signal Transducer and Activator of Transcription 3 (STAT3) Pathway
por: Xie, Dongyu, et al.
Publicado: (2019)

Phosphorylated transducer and activator of transcription-3 (pSTAT3) immunohistochemical expression in paired primary and metastatic colorectal cancer
por: Marginean, Esmeralda C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g1coi3apoovhv6hefa05i94kdf