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A Temporal Threshold for Formaldehyde Crosslinking and Fixation

BACKGROUND: Formaldehyde crosslinking is in widespread use as a biological fixative for microscopy and molecular biology. An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length of time required for an interaction to become...

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Detalles Bibliográficos
Autores principales: Schmiedeberg, Lars, Skene, Pete, Deaton, Aimée, Bird, Adrian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645674/
https://www.ncbi.nlm.nih.gov/pubmed/19247482
http://dx.doi.org/10.1371/journal.pone.0004636