Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

BACKGROUND: Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved. METHODOLOGY/PRINCIPAL FINDINGS:...

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Detalles Bibliográficos
Autores principales: Cheng, Gang, Tse, Janet, Jain, Rakesh K., Munn, Lance L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645686/
https://www.ncbi.nlm.nih.gov/pubmed/19247489
http://dx.doi.org/10.1371/journal.pone.0004632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645686/
https://www.ncbi.nlm.nih.gov/pubmed/19247489
http://dx.doi.org/10.1371/journal.pone.0004632

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