Phosphorylation of p53 Is Regulated by TPX2-Aurora A in Xenopus Oocytes

p53 is an important tumor suppressor regulating the cell cycle at multiple stages in higher vertebrates. The p53 gene is frequently deleted or mutated in human cancers, resulting in loss of p53 activity. This leads to centrosome amplification, aneuploidy, and tumorigenesis, three phenotypes also obs...

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Detalles Bibliográficos
Autores principales: Pascreau, Gaetan, Eckerdt, Frank, Lewellyn, Andrea L., Prigent, Claude, Maller, James L.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Molecular Basis of Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645813/
https://www.ncbi.nlm.nih.gov/pubmed/19121998
http://dx.doi.org/10.1074/jbc.M805959200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645813/
https://www.ncbi.nlm.nih.gov/pubmed/19121998
http://dx.doi.org/10.1074/jbc.M805959200

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