Cargando…

Lipoic Acid Synthase (LASY): A Novel Role in Inflammation, Mitochondrial Function, and Insulin Resistance

OBJECTIVE—Lipoic acid synthase (LASY) is the enzyme that is involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant. The aim of this study was to study the role of LASY in type 2 diabetes. RESEARCH DESIGN AND METHODS—We studied expression of LASY in animal models of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Padmalayam, Indira, Hasham, Sumera, Saxena, Uday, Pillarisetti, Sivaram
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646058/ https://www.ncbi.nlm.nih.gov/pubmed/19074983 http://dx.doi.org/10.2337/db08-0473

Ejemplares similares

Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Lepr(db/db) mice
por: Zhao, Yingzheng, et al.
Publicado: (2021)

A Case of Insulin Autoimmune Syndrome in an Indian Male Taking Alpha-Lipoic Acid
por: Sehgal, Tanisha, et al.
Publicado: (2023)

Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
por: Attané, Camille, et al.
Publicado: (2012)

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
por: Sachithanandan, Nirupa, et al.
Publicado: (2011)

Characterization of Helianthus annuus Lipoic Acid Biosynthesis: The Mitochondrial Octanoyltransferase and Lipoyl Synthase Enzyme System
por: Martins-Noguerol, Raquel, et al.
Publicado: (2021)

Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
por: Fisher-Wellman, Kelsey H., et al.
Publicado: (2014)

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation
por: Fazakerley, Daniel J., et al.
Publicado: (2018)

Effect of vitamin E and alpha lipoic acid on intestinal development associated with wooden breast myopathy in broilers
por: Wang, Ji, et al.
Publicado: (2020)

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
por: Høeg, Louise D., et al.
Publicado: (2011)

Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
por: Leproult, Rachel, et al.
Publicado: (2014)

Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review
por: Abubaker, Saleh A, et al.
Publicado: (2022)

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
por: Boon, James, et al.
Publicado: (2013)

Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
por: Lidor, O., et al.
Publicado: (2015)

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
por: Hoeks, Joris, et al.
Publicado: (2010)

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance
por: Henstridge, Darren C., et al.
Publicado: (2014)

Delayed Skeletal Muscle Mitochondrial ADP Recovery in Youth With Type 1 Diabetes Relates to Muscle Insulin Resistance
por: Cree-Green, Melanie, et al.
Publicado: (2015)

Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes
por: Tedesco, Laura, et al.
Publicado: (2008)

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance
por: Kawano, Yoshinaga, et al.
Publicado: (2012)

Branched-chain fatty acids affect the expression of fatty acid synthase and C-reactive protein genes in the hepatocyte cell line
por: Gozdzik, Paulina, et al.
Publicado: (2023)

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
por: Halperin, Florencia, et al.
Publicado: (2012)

Enzamin ameliorates adipose tissue inflammation with impaired adipocytokine expression and insulin resistance in db/db mice
por: Tamura, Yukinori, et al.
Publicado: (2013)

The Effect of Alpha-Lipoic Acid on Diabetic Peripheral Neuropathy and the Upcoming Depressive Disorders of Type II Diabetics
por: Karalis, Dimitrios T, et al.
Publicado: (2021)

Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy
por: Xu, Longquan, et al.
Publicado: (2016)

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation
por: Lee, Hui-Young, et al.
Publicado: (2017)

Corrigendum: Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
por: Lidor, O., et al.
Publicado: (2016)

Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes
por: Zeng, Mengqi, et al.
Publicado: (2021)

A(2B) Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation
por: Csóka, Balázs, et al.
Publicado: (2014)

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
por: Lord, Caleb C., et al.
Publicado: (2012)

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
por: Steneberg, Pär, et al.
Publicado: (2015)

Failure of Homeostatic Model Assessment of Insulin Resistance to Detect Marked Diet-Induced Insulin Resistance in Dogs
por: Ader, Marilyn, et al.
Publicado: (2014)

Lipid-Induced Insulin Resistance Is Not Mediated by Impaired Transcapillary Transport of Insulin and Glucose in Humans
por: Szendroedi, Julia, et al.
Publicado: (2012)

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
por: Vazirani, Reema P., et al.
Publicado: (2016)

Dipeptidyl Peptidase-4 Inhibition Ameliorates Western Diet–Induced Hepatic Steatosis and Insulin Resistance Through Hepatic Lipid Remodeling and Modulation of Hepatic Mitochondrial Function
por: Aroor, Annayya R., et al.
Publicado: (2015)

Progress in the Enzymology of the Mitochondrial Diseases of Lipoic Acid Requiring Enzymes
por: Cronan, John E.
Publicado: (2020)

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle
por: Drew, Brian G., et al.
Publicado: (2014)

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery
por: Coen, Paul M., et al.
Publicado: (2015)

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity
por: Tol, Marc J., et al.
Publicado: (2016)

Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women
por: Bonnet, Fabrice, et al.
Publicado: (2011)

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion
por: Stark, Romana, et al.
Publicado: (2009)

Relationships of surrogate indexes of insulin resistance with insulin sensitivity assessed by euglycemic hyperinsulinemic clamp and subclinical vascular damage
por: Fiorentino, Teresa Vanessa, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jn80ot7gu4pnd1n0pg64pc6fj0