Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy

We have developed a global strategy based on the Bayesian network framework to prioritize the functional modules mediating genetic perturbations and their phenotypic effects among a set of overlapping candidate modules. We take lethality in Saccharomyces cerevisiae and human cancer as two examples t...

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Detalles Bibliográficos
Autores principales: Wang, Li, Sun, Fengzhu, Chen, Ting
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646278/
https://www.ncbi.nlm.nih.gov/pubmed/19087245
http://dx.doi.org/10.1186/gb-2008-9-12-r174
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author Wang, Li
Sun, Fengzhu
Chen, Ting
author_facet Wang, Li
Sun, Fengzhu
Chen, Ting
author_sort Wang, Li
collection PubMed
description We have developed a global strategy based on the Bayesian network framework to prioritize the functional modules mediating genetic perturbations and their phenotypic effects among a set of overlapping candidate modules. We take lethality in Saccharomyces cerevisiae and human cancer as two examples to show the effectiveness of this approach. We discovered that lethality is more conserved at the module level than at the gene level and we identified several potentially 'new' cancer-related biological processes.
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spelling pubmed-26462782009-02-23 Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy Wang, Li Sun, Fengzhu Chen, Ting Genome Biol Method We have developed a global strategy based on the Bayesian network framework to prioritize the functional modules mediating genetic perturbations and their phenotypic effects among a set of overlapping candidate modules. We take lethality in Saccharomyces cerevisiae and human cancer as two examples to show the effectiveness of this approach. We discovered that lethality is more conserved at the module level than at the gene level and we identified several potentially 'new' cancer-related biological processes. BioMed Central 2008 2008-12-16 /pmc/articles/PMC2646278/ /pubmed/19087245 http://dx.doi.org/10.1186/gb-2008-9-12-r174 Text en Copyright © 2008 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Wang, Li
Sun, Fengzhu
Chen, Ting
Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title_full Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title_fullStr Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title_full_unstemmed Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title_short Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
title_sort prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646278/
https://www.ncbi.nlm.nih.gov/pubmed/19087245
http://dx.doi.org/10.1186/gb-2008-9-12-r174
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AT sunfengzhu prioritizingfunctionalmodulesmediatinggeneticperturbationsandtheirphenotypiceffectsaglobalstrategy
AT chenting prioritizingfunctionalmodulesmediatinggeneticperturbationsandtheirphenotypiceffectsaglobalstrategy

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