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Kinetochore stretching inactivates the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain...

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Detalles Bibliográficos
Autores principales: Uchida, Kazuhiko S.K., Takagaki, Kentaro, Kumada, Kazuki, Hirayama, Youko, Noda, Tetsuo, Hirota, Toru
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646554/
https://www.ncbi.nlm.nih.gov/pubmed/19188492
http://dx.doi.org/10.1083/jcb.200811028