Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103(+) inducible regulatory T cells

Growth factor independent 1 (Gfi-1), a transcriptional repressor, is transiently induced during T cell activation. Interleukin (IL) 4 further induces Gfi-1, resulting in optimal Th2 cell expansion. We report a second important function of Gfi-1 in CD4 T cells: prevention of alternative differentiati...

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Detalles Bibliográficos
Autores principales: Zhu, Jinfang, Davidson, Todd S., Wei, Gang, Jankovic, Dragana, Cui, Kairong, Schones, Dustin E., Guo, Liying, Zhao, Keji, Shevach, Ethan M., Paul, William E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646571/
https://www.ncbi.nlm.nih.gov/pubmed/19188499
http://dx.doi.org/10.1084/jem.20081666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646571/
https://www.ncbi.nlm.nih.gov/pubmed/19188499
http://dx.doi.org/10.1084/jem.20081666

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