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Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103(+) inducible regulatory T cells
Growth factor independent 1 (Gfi-1), a transcriptional repressor, is transiently induced during T cell activation. Interleukin (IL) 4 further induces Gfi-1, resulting in optimal Th2 cell expansion. We report a second important function of Gfi-1 in CD4 T cells: prevention of alternative differentiati...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646571/ https://www.ncbi.nlm.nih.gov/pubmed/19188499 http://dx.doi.org/10.1084/jem.20081666 |