Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain

Adoptive transfer of T lymphocytes transduced with a T cell receptor (TCR) to impart tumor reactivity has been reported as a potential strategy to redirect immune responses to target cancer cells (Schumacher, T.N. 2002. Nat. Rev. Immunol. 2:512–519). However, the affinity of most TCRs specific for s...

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Detalles Bibliográficos
Autores principales: Kuball, Jürgen, Hauptrock, Beate, Malina, Victoria, Antunes, Edite, Voss, Ralf-Holger, Wolfl, Matthias, Strong, Roland, Theobald, Matthias, Greenberg, Philip D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646573/
https://www.ncbi.nlm.nih.gov/pubmed/19171765
http://dx.doi.org/10.1084/jem.20082487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646573/
https://www.ncbi.nlm.nih.gov/pubmed/19171765
http://dx.doi.org/10.1084/jem.20082487

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