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Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
Adoptive transfer of T lymphocytes transduced with a T cell receptor (TCR) to impart tumor reactivity has been reported as a potential strategy to redirect immune responses to target cancer cells (Schumacher, T.N. 2002. Nat. Rev. Immunol. 2:512–519). However, the affinity of most TCRs specific for s...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646573/ https://www.ncbi.nlm.nih.gov/pubmed/19171765 http://dx.doi.org/10.1084/jem.20082487 |