CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

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Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4–deficient mice develop fatal, early onset lymphoproliferative disease. However, chimer...

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Detalles Bibliográficos
Autores principales: Friedline, Randall H., Brown, David S., Nguyen, Hai, Kornfeld, Hardy, Lee, JinHee, Zhang, Yi, Appleby, Mark, Der, Sandy D., Kang, Joonsoo, Chambers, Cynthia A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646578/
https://www.ncbi.nlm.nih.gov/pubmed/19188497
http://dx.doi.org/10.1084/jem.20081811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646578/
https://www.ncbi.nlm.nih.gov/pubmed/19188497
http://dx.doi.org/10.1084/jem.20081811

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