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CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4–deficient mice develop fatal, early onset lymphoproliferative disease. However, chimer...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646578/ https://www.ncbi.nlm.nih.gov/pubmed/19188497 http://dx.doi.org/10.1084/jem.20081811 |
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por Friedline, Randall H., Brown, David S., Nguyen, Hai, Kornfeld, Hardy, Lee, JinHee, Zhang, Yi, Appleby, Mark, Der, Sandy D., Kang, Joonsoo, Chambers, Cynthia A.
Publicado 2009
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Publicado 2009
Enlace del recurso
Texto