Role of the Acidic Hirudin-like COOH-Terminal Amino Acid Region of Factor Va Heavy Chain in the Enhanced Function of Prothrombinase‡

[Image: see text] Prothrombinase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271). This pathway is characterized by the generation of an enzymatically active, transient intermediate, meizothrombin, that has increased chromogenic substrate activity but poor...

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Detalles Bibliográficos
Autores principales: Hirbawi, Jamila, Bukys, Michael A., Barhoover, Melissa A., Erdogan, Evrim, Kalafatis, Michael
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646660/
https://www.ncbi.nlm.nih.gov/pubmed/18590276
http://dx.doi.org/10.1021/bi800593k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646660/
https://www.ncbi.nlm.nih.gov/pubmed/18590276
http://dx.doi.org/10.1021/bi800593k

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