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Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
[Image: see text] The 1,3-dipolar cycloaddition of azides and activated alkynes has been used for site-selective labeling of biomolecules in vitro and in vivo. While copper catalysis has been widely employed to activate terminal alkynes for [3 + 2] cycloaddition, this method, often termed “click che...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646667/ https://www.ncbi.nlm.nih.gov/pubmed/18680289 http://dx.doi.org/10.1021/ja803086r |