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Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective

Type II DNA topoisomerases (topos) are essential and ubiquitous enzymes that perform important intracellular roles in chromosome condensation and segregation, and in regulating DNA supercoiling. Eukaryotic topo II, a type II topoisomerase, is a homodimeric enzyme that solves topological entanglement...

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Detalles Bibliográficos
Autores principales: Collins, Tammy R. L., Hammes, Gordon G., Hsieh, Tao-shih
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647300/
https://www.ncbi.nlm.nih.gov/pubmed/19155278
http://dx.doi.org/10.1093/nar/gkn1059