Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

BACKGROUND: In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the α-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits. Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results...

Descripción completa

Detalles Bibliográficos
Autores principales: Prinzen, Claudia, Trümbach, Dietrich, Wurst, Wolfgang, Endres, Kristina, Postina, Rolf, Fahrenholz, Falk
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647556/
https://www.ncbi.nlm.nih.gov/pubmed/19196476
http://dx.doi.org/10.1186/1471-2164-10-66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647556/
https://www.ncbi.nlm.nih.gov/pubmed/19196476
http://dx.doi.org/10.1186/1471-2164-10-66

Ejemplares similares