A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

How cell numbers are determined is not understood. Hedgehog-Gli activity is involved in precursor cell proliferation and stem cell self-renewal, and its deregulation sustains the growth of many human tumours. However, it is not known whether GLI1, the final mediator of Hh signals, controls stem cell...

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Detalles Bibliográficos
Autores principales: Stecca, Barbara, Ruiz i Altaba, Ariel
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647769/
https://www.ncbi.nlm.nih.gov/pubmed/19214186
http://dx.doi.org/10.1038/emboj.2009.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647769/
https://www.ncbi.nlm.nih.gov/pubmed/19214186
http://dx.doi.org/10.1038/emboj.2009.16

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