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A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
How cell numbers are determined is not understood. Hedgehog-Gli activity is involved in precursor cell proliferation and stem cell self-renewal, and its deregulation sustains the growth of many human tumours. However, it is not known whether GLI1, the final mediator of Hh signals, controls stem cell...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647769/ https://www.ncbi.nlm.nih.gov/pubmed/19214186 http://dx.doi.org/10.1038/emboj.2009.16 |