Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors

We have recently identified several novel ATP-independent inhibitors that target the extracellular signal-regulated kinase-2 (ERK2) protein and inhibit substrate phosphorylation. To further characterize these compounds, we describe the use of C. elegans as a model organism. C. elegans is recognized...

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Detalles Bibliográficos
Autores principales: Chen, Fengming, MacKerell, Alexander D., Luo, Yuan, Shapiro, Paul
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648047/
https://www.ncbi.nlm.nih.gov/pubmed/19105050
http://dx.doi.org/10.1007/s12079-008-0034-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648047/
https://www.ncbi.nlm.nih.gov/pubmed/19105050
http://dx.doi.org/10.1007/s12079-008-0034-2

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