Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

BACKGROUND: The antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. Integrins are also widely expressed in malignant glioma and integrin inhibitors may directly target tumor cells in this disease. Aim of the curr...

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Detalles Bibliográficos
Autores principales: Oliveira-Ferrer, Leticia, Hauschild, Jessica, Fiedler, Walter, Bokemeyer, Carsten, Nippgen, Johannes, Celik, Ilhan, Schuch, Gunter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648308/
https://www.ncbi.nlm.nih.gov/pubmed/19114005
http://dx.doi.org/10.1186/1756-9966-27-86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648308/
https://www.ncbi.nlm.nih.gov/pubmed/19114005
http://dx.doi.org/10.1186/1756-9966-27-86

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