Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells

We have previously shown that the death receptor ligand TRAIL induces an increase in intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide leading us to propose that defective ceramide signaling contributes to T...

Descripción completa

Detalles Bibliográficos
Autores principales: White-Gilbertson, S., Mullen, T., Senkal, C., Lu, P., Ogretmen, B., Obeid, L., Voelkel-Johnson, C.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648838/
https://www.ncbi.nlm.nih.gov/pubmed/19137010
http://dx.doi.org/10.1038/onc.2008.468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648838/
https://www.ncbi.nlm.nih.gov/pubmed/19137010
http://dx.doi.org/10.1038/onc.2008.468

Ejemplares similares